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Importantly, the current evidence supporting this approach is largely indirect and derived from studies conducted in patients with established PsO and metabolic comorbidities, rather than in well-characterized early PsA cohorts.An additional and largely underexplored aspect concerns the safety of combining GLP-1RAs with bDMARDs

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These reviews are part of a commission from the World Health Organization (WHO) to the Cochrane Evidence Synthesis Units (ESU) in Iberoamericacoordinated by the Iberoamerican Cochrane Centre , based at IR Sant Pauand Germany and the United Kingdom and will inform upcoming WHO guidelines on the use of GLP-1 receptor agonists for treating obesity

The epidemiology of obesity