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In clinical trials, many patients who used Zepbound reported a substantial decrease in appetite, which led to improved adherence to their weight loss goals
The studys investigator, Henning Bliddal, MD, is intrigued by whether or not theres a specific action of GLP-1 receptor agonists on the joint, not through weight loss but by itself. In addition to pain and weight reduction, those studied also had improved WOMAC physical function scores from baseline
The transcription factor ATF4 in turn activates stress-responsive genes such as Tribbles homolog 3 (Trib3) and solute carrier family 7 member 11 (Slc7A11) to mediate protective effects of the integrative stress response 16
Zepbound through Shed starts at $349 per month, and the price increases with higher doses
