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Semaglutide, a type of GLP-1R agonists with 94% sequence homology to GLP-1 and with an extended half-life of approximately 1 week, has been clinically approved to treat T2DM and is available in subcutaneous and oral dosage form (136, 137)
Room temperature exposure degrades the compound, and repeated temperature cycling (cold to warm and back) can reduce potency faster than consistent refrigeration
An ovarian cyst can cause torsion (forcing the ovary to twist), potentially cutting off the blood supply to the tissue
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