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Severe liver damage may develop fully within 72 hours

Hudachek SF, Gustafson DL

Your doctor should know if you have a history of: Pancreatitis (acute or chronic)both medications carry warnings about pancreatitis risk Severe gastrointestinal disease , including gastroparesis, which may be exacerbated by GLP-1-based therapies Renal impairment sitagliptin requires dose adjustment based on eGFR, while tirzepatide does not require dose adjustment, though caution is advised with dehydration Thyroid disease Mounjaro's UK SmPC notes that rodent studies showed an increased incidence of thyroid C-cell tumours, though the relevance to humans is unknown