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This reporting is essential for building the safety evidence base that regulators such as the MHRA rely upon when assessing new medicines
Deficiency of G6PD affects HMP Shunt in the lens that leads to shortening of ribose availability for the synthesis of nucleic acid and decreases the renewal of lens proteins
In the context of the Melanotan II pathway, this is relevant because Melanotan II is a melanocortin receptor agonist, and MC1R is one of the receptor-family members that responds to melanocortin-related signaling
This technical difference is a key point in the defenses argument
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