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This raises questions about cost-effectiveness and access, but if priced reasonably or if generics eventually become available, we may see a broad shift where anti-obesity pharmacotherapy (especially GLP-1/GIP-based) is as commonplace as antihypertensive or lipid-lowering therapy

This SGLT1-dependent mechanism is the basis for the early elevation of plasma GLP-1 and GIP levels after carbohydrate intake (Zhu et al., 2022)

Importantly, their influence extends to skeletal muscle, where GLP-1 RAs promote glucose uptake via the AMP-activated protein kinase pathway, increase vascular blood flow, and mitigate glucotoxicity, thereby supporting muscle protein synthesis and inhibiting catabolic pathways [14, 15]

Testes: GLP-1 reduces inflammation, indicating possible fertility benefits