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In related studies, Michael Nauck observed in 1986 that the incretin effect was lost or severely reduced in people with type 2 diabetes [10], making it unlikely that incretins would be useful therapeutically

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The dosing schedule begins with a small introductory dosage of 0.25 mg and is increased slowly until a therapeutic dosage (a dose which provides good hunger suppression, minimal side effects, and consistent weight loss) is reached or the highest FDA-approved dose, 2.4 mg, is reached