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A deficiency also reduces glutamate uptake in neurons, which ordinarily helps to reduce extracellular glutamate concentrations, and this occurs likely through downregulation of GLT-1 and GLAST glutamate transporters

Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future

MT2 reduces the UV dose required to achieve a given pigmentation level by 4060%, because it pre-activates melanogenesis pathways that would normally require higher UV intensity to trigger

Full-body brightening usually needs a course rather than a single shot commonly 6 to 12 sessions spaced about one to two weeks apart, followed by maintenance