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The STEP 1 trial alone showed participants achieving 14.9% mean body weight reduction over 68 weeks when following proper dosing escalation
NNMT catalyzes transfer of a methyl group from S-adenosyl-L-methionine (SAM) to nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosyl-L-homocysteine
In terms of documented efficacy, this is not a close comparison: GLP-1 S has shown weight reductions in the range of 13-20% of body weight in clinical trials, while AOD-9604s pivotal trial failed to demonstrate a significant effect at that scale
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