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[13] [14] UK SmPCs for licensed GLP-1 receptor agonists do not list medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) as formal contraindications, but advise vigilance for symptoms such as a neck lump, hoarseness, or difficulty swallowing
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56,57 Accordingly, whether contact-dependent spread reflects a fundamentally distinct transmission mechanism or instead emerges, in part, from density-conditioned membrane architecture remains an important consideration
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