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Nat Rev Gastroenterol Hepatol 2013;10:57584

Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)

References Abdel-Bakky MS, Hammad MA, Walker LA, Ashfaq MK (2011) Tissue factor dependent liver injury causes release of retinoid receptors (RXR- and RAR-) as lipid droplets