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Trans-omic integration highlights AKT1-linked metabolic signatures in advanced lipedema Given the broad metabolic impact of the phosphoinositide 3-kinase (PI3K)-AKT signaling pathway, whose aberrant activation can modulate multiple metabolic processes through direct and indirect mechanisms, we next investigated the metabolic alterations in lipedema using untargeted metabolomics [49, 50]

For principal component analysis (PCA), counts of each cell group/mouse for each genotype where extracted and analyzed using DESeq2 129

To perform these functions, it must be present in a so-called reduced form

DNA dot-blots for 5-mC and 5-hmC revealed the patterns created by the events of the epigenetic modification enzymes