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In the future, longitudinal studies will be necessary to capture trajectories of changes over time in AC levels and depressive symptoms in order to properly disentangle trait vs state effects and provide empirical grounding for causal interpretation, triangulating evidence with experimental medicine approaches

As a cytoprotective agent, mediating Roberts cytoprotection, it maintains endothelium integrity and has a particular angiomodulatory effect (Sikiric et al., 1993
TEER measurement techniques for in vitro barrier model systems

ROS is also required for optimal NLRP3 inflammasome activation (37, 38)

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