While GLP-1 agonists are primarily administered via subcutaneous injections, efforts are underway to develop alternative delivery methods, such as oral formulations and once-weekly injections, to improve patient adherence and convenience
It includes a C-18 fatty acid chain attached to the peptide backbone that enables it to bind to albumin in the blood, extending its half-life to approximately one week
Among these, the MUC5B promoter variant (rs35705950) is the most prominent, conferring a greater than threefold increased risk for IPF and exceeding the effect of all other known variants combined [21, 22]
- Oral semaglutide is effective, safe and well tolerated in patients with DM2, even in those with DKD, with the benefits inherent to this family of drugs, which may facilitate the earlier introduction of an arGLP-1 in the management of DM2