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First, phase II clinical trials evaluating MOTS-c in type 2 diabetes and sarcopenia are in development, and their results will provide the first randomized controlled evidence in humans to define therapeutic doses with statistical rigor

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In the reprogramming model, the findings were evaluated by focusing mainly on the appearance of hyperplastic and dysplastic changes of the epithelial cells of the digestive mucosa and pancreatic acini

P values for unpaired comparisons between two groups with comparable variance were calculated by two-tailed Students t -test