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HPV16 E6 and E7 proteins induce a chronic oxidative stress response via NOX2 that causes genomic instability and increased susceptibility to DNA damage in head and neck cancer cells

In primary culture of satellite cells, the LASSS-treated HGF (Figure 1f, bars 9 and 11 , at 5 ng/ml without or with exposure to peroxynitrite, respectively) normally activates satellite cells to a level equivalent to the positive control ( bar 2 ) as revealed by BrdU-incorporation assay