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Yu YP, Yu G, Tseng G, Cieply K, Nelson J, Defrances M, Zarnegar R, Michalopoulos G, Luo JH

In chondrocytes, ferroptosis occurs primarily due to oxidative stress, iron overload, and impaired antioxidant defense mechanisms such as reduced activity of glutathione peroxidase 4 (GPX4) and the cystine/glutamate antiporter system Xc

Too much vigorous exercise however, such as cardio and crossfit, can often deplete glutathione levels in the body

Experimental observations suggest that the mitigation of microRNA 146a expression may reverse the suppressive implications of thymosin beta 4 on IRAK1 and TRAF6 signaling activity