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Key Takeaways GLP-1 medications slow digestion, which can lead to nausea, bloating, reflux, gas, and changes in bowel habits
While many existing drugs for T2DM and obesity target the GLP-1R alone, the ability of tirzepatide to act on both incretin receptors seems to provide synergistic or at least additive benefits [18]
Similarly, although medullary thyroid cancer has been linked to GLP-1RAs in rodent studies, there have been very few or no reports of medullary thyroid cancer in clinical trials [4, 9, 67, 68]
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