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The underlying mechanisms involve critical biochemical processes such as DNA synthesis, methylation reactions, neurotransmitter production, and myelin synthesis, all of which are essential for the proper functioning and maintenance of the nervous system

Riccardi, C

10.1126/science.276.5309.122 Summary Keywords busulfan, population pharmacokinetics, glutathione S-transferase activity, precision dosing, pediatric transplantation, virtual clinical trial Citation Cao D, Qian X, Wang P, Zheng X, Huang S, Wei Z, Jiang W, Yu L, Jiang X, Yu Y, Mao J and Zhai X (2025) Semi-mechanistic population pharmacokinetic model incorporating glutathione S-transferase activity for personalized busulfan dosing in pediatric allogeneic hematopoietic cell transplantation

The kidneys are particularly sensitive to this imbalance for two reasons: their high oxygen consumption and their exposure to various compounds they are filtering from the blood