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Implications During Pregnancy: While the benefits of GLP-1 in weight management are promising, studies like those in the British Journal of Clinical Pharmacology emphasize the need for cautious consideration during pregnancy

A 2025 University of Virginia study concluded that while GLP-1 drugs significantly reduce body weight and adiposity, they do so "with no clear evidence of cardiorespiratory fitness enhancement"a critical finding given that cardiorespiratory fitness is among the most potent predictors of all-cause and cardiovascular mortality [48]

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Patients on liver, kidney, or cardiovascular surgery need medical approval