glp-1 agonists and sglt2 inhibitors Receptor in Diabetic Kidney Disease: Evolving Evidence and Clinical Application Criteria for recommendation of SGLT2

Thats because it breaks down in the gastrointestinal tract

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Glutathione, catalyzed by the enzyme Glutathione S-Transferase, conjugates to these molecules, increasing their solubility and transporting them out of the cells to be excreted in urine or bile

Diuretics used in the treatment of CHF have been found to increase thiamin excretion, potentially leading to thiamin deficiency