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In comparative studies, this combination has demonstrated additive effects on weight loss by targeting two distinct neuroendocrine pathways: the hindbrain (area postrema) via amylin agonism and the hypothalamus via GLP-1 agonism

Commenting on the results, Novo Nordisk chief scientific officer Martin Holst Lange pointed out that the weight loss numbers were comparable to what's achievable through injection -- no needles required

Hair and nail improvements, slower to develop than skin changes, often become notable during extended use

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