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Repurposing GLP-1 receptor agonists and novel dual/triple GLP-1, GIP, and glucagon agonists represent promising therapeutic strategies that have shown to be effective in targeting inflammation, tau phosphorylation, synaptic dysfunction, insulin resistance, and oxidative stress
It has been found that PPARGC1A is a transcriptional coactivator that drives the transformation of fast- to slow-twitch fibers via various biological pathways (e.g., glycolysis, the TCA cycle, and fatty acid -oxidation)
E.MannervikB.et al
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