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This is particularly noteworthy because two competing oral small-molecule GLP-1 programs from Pfizer, lotiglipron (discontinued in 2023) and danuglipron (discontinued in April 2025), were terminated due to liver toxicity concerns

Researchers continue evaluating these interconnected pathways to better characterize intracellular signaling mechanisms and peptide pharmacology in laboratory models

Common side effects of Semaglutide include nausea, diarrhea, and mild digestive discomfort, which often improve as your body adjusts to the medication

What You Should Know About Side Effects and Results Managing Common Side Effects Like any prescription drug, semaglutide can cause side effects when you first start therapy or increase your dose