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The following skin parameters were recorded: hydration (corneometer), TEWL (tewameter), desquamation (standard D-Squame disc), wrinkles (trained dermatologist grading scale and PRIMOS 3D imaging system), and elasticity (ballistometer) at 4, 8, and 12 weeks
The strongest support comes from clinical evidence focused on treating vitamin B12 deficiency, not from general wellness claims What science supports The NIH Fact Sheet for Health Professionals shows that intramuscular B12 injections are effective at raising blood B12 levels and correcting deficiency
This is in line with earlier findings that up-regulation of PR-1a is a reliable marker of the SA mediated defense pathway (Ward et al., 1991
