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b Estimated using an ANCOVA model based on data irrespectively of discontinuation of trial product or initiation of rescue medication adjusted for baseline value and region
Quality can vary between pharmacies, concentrations may differ from batch to batch, and the responsibility for accurate dosing shifts from the manufacturer to the user
However, hepatic production of cysteine is limited and cysteine-deficient status is associated with numerous diseases such as insulin resistance, immune dysfunction and cancer 1
Specific statistical tests are indicated in Extended Data Table 3, and results are available for each data panel in the supplementary raw data files
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