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Those are different regulatory categories with different oversight structures

There were 23 clinical studies published between 2020 and 2025 that support collagen as a nutraceutical treatment that showed improvement in various skin attributes, but investigations are lacking on collagens effectiveness on scalp, hair, and nail health, which warrants further examination

We also excluded patients with no diagnosis of type 2 diabetes ever before cohort entry, as well as those with diagnosed contraindications for the study drugsnamely, end stage renal disease and multiple endocrine neoplasia syndrome, assessed ever before cohort entry

while the SHAM group was exposed to air during the same period of time as previously described (Al-Odat et al., 2015)