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In the multicenter PIVENS ( PI oglitazone versus V itamin E versus placebo for the treatment of N onalcoholic S teatohepatitis) trial, 247 subjects with MASH but not diabetes mellitus were randomized to receive 30 mg/day of pioglitazone (an insulin-sensitizing drug), 800 IU/day (536 mg/day) of RRR --tocopherol, or a placebo for 96 weeks (97)
This can impact methylation, detoxification, neurotransmitters, and energy production
Yadav UC, Ramana KV, Aguilera-Aguirre L, Boldogh I, Boulares HA, Srivastava SK
Its very important to find and treat these problems early
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