semaglutide peak plasma SPE-LC/MS Bioanalytical Quantification of the Biotherapeutic Peptide, From Mean plasma concentration-time profiles for

Summary: This study presents a series of cases where patients on glucagon-like peptide-1 receptor agonists, including semaglutide, tested positive for amphetamines in urine drug screenings

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The proposed tiered diagnostic framework, emphasis on stage-dependent endocrine failure, and recognition of distinct PDM endotypes aim to improve diagnostic accuracy, reduce misclassification, and support individualized metabolic and nutritional care