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Most are gastrointestinal and usually mild: Nausea (often improves after 24 weeks) Diarrhea or constipation Bloating or abdominal discomfort Reduced appetite (that one's the point) Fatigue in the first few weeks To minimize them: follow the titration schedule, eat smaller meals, go easy on greasy/high-fat foods, stay hydrated, and consider injecting at bedtime

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