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Meanwhile, resveratrol regulates the metabolism of leucine and tryptophan as well as metabolites such as hydroxyphenyllactic acid and isopalmitic acid, restores the level of citric acid in the TCA cycle, regulates fatty acid metabolism through the PPAR pathway, and integrates deacetylation with SIRT1 as the hub, thereby synchronously improving mitochondrial function and the immune-inflammatory network, and inhibiting pulmonary vascular remodeling and right ventricular damage (Vazquez-Garza et al., 2020