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People commonly experience some or all of the following side effects after stopping GLP-1 medications, says Goddard: Increased hunger (often noticeably stronger) Food noise, often described as the persistent mental chatter about eating and cravings Weight regain, which research shows can begin within weeks Changes in blood sugar control, particularly for people with type 2 diabetes Loss of some cardiometabolic benefits gained during treatment Improvement in GLP-1-related side effects such as nausea, constipation and bloating Not everyone experiences every one of these changes, and their severity varies widely
Users who find this holding period difficult should know that it represents one of the most significant factors in determining how much tirzepatide actually reaches their bloodstream
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One important regulatory update to know is that in December 2024, the FDA confirmed that the tirzepatide shortage had been resolved [1]
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