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Lancet HIV, 6(12), e821e830
Pyridoxine (B) in high doses is known to interact with certain drugs: it can reduce the therapeutic efficacy of levodopa by increasing peripheral conversion of levodopa to dopamine (vitamin B speeds up decarboxylation)
B12 plays an important role in the recycling of N5-methyl THF (the storage form of folate) to THF, the form of folate that serves as a coenzyme for numerous metabolic reactions involving amino acids and nucleic acids
Series 2: 3-AR knock-out mice (the gene for the 3 receptor is knocked out) in the same design, to check whether 3 is necessary for the AOD-9604 effect
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