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Int J Mol Sci 21(21):8187
This mechanism was confirmed by the evidence that erythrocytes isolated from smokers exhibited higher levels of membrane-recruited caspase-8 and FADD than non-smokers
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Moreover, it has been reported that Rheb undergoes K48-linked polyubiquitination under low glucose availability, leading to the inactivation of mTORC1 (Li et al, 2024), which suggests the essentiality of regulating Rheb levels and activity during glucose starvation
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