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Animal safety data has not identified a toxic dose, but that does not replace physician guidance

Many patients do extremely well on the lower end when paired with a topical 2 %3 % serum and good sun protection

The primary underlying pathomechanism is most likely a decreased hepatic GHR expression related to insulin deficiency, resulting in GH-resistance and impaired hepatic IGF-1 synthesis, which stimulates pituitary GH-secretion by a feedback mechanism [188, 189]

The oral route delivers BPC-157 through the GI tract, which is where the original peptide sequence was identified and where its gastroprotective properties are most mechanistically direct