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Tirzepatide distinguishes itself by acting as a dual agonist, engaging both GLP-1 and GIP receptors

[7] In a Bayesian network meta-analysis of 48 randomized trials and nearly 28,000 participants, the dominant gastrointestinal events were nausea (about 21.5%), diarrhea (10.6%), vomiting (9.1%), and constipation (7.9%), with semaglutide carrying one of the highest constipation risks