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Rather than mixing the powder into a large glass of water and swallowing it immediately, the manufacturer and functional medicine practitioners recommend placing the powder directly in the mouth (or mixing it with a tiny sip of water) and holding it under the tongue or against the cheeks for 30 to 90 seconds before swallowing
Nat Methods (2016) 13:3528
& Mansson, J
It has been suggested that GLUD1 assumes in its basal state a configuration (open catalytic cleft) that permits catalytic activity regardless of whether the allosteric sites are functional
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