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Group design and comparative analysis Comparative safety profile: GLP-1 receptor agonist monotherapy versus combination therapy with metformin The pharmacovigilance analysis encompassed 262,355 adverse event (AE) reports associated with GLP-1 receptor agonist therapy

Differential implication of glutathione, glutathione-metabolizing enzymes and ascorbate in tomato resistance to Pseudomonas syringae

Mutations in these regions can disturb GTP binding and lead to decreased sensitivity of GDH to allosteric regulation by GTP, resulting in weakened inhibitory effect and enhanced GDH activity [12]

The EC50 of GLP1 (7-36) is in the expected 2 digits pM range (25-60pM), while its metabolite shows a potency which is 4 logs lower and falls into the low M range