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Long-term use of the Mirena intrauterine system for heavy menstrual bleeding: A retrospective cohort study

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J Altern Complement Med 2008;14(2):139-146

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Key mediators such as irisin, BDNF, IL-6, adiponectin, FGF21, and apelin each contribute distinct yet complementary protective actions: irisin inhibits NLRP3 inflammasome activation, attenuates oxidative stress, and reduces pyroptotic cell death (215)

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Some people also rely heavily on caffeine, which can compound fluid loss if intake is excessive, she says

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