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Pinching the skin at the injection site creates a raised area of subcutaneous tissue, reducing the distance the needle must travel and lowering the risk of intramuscular delivery
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The SLIMMER-UP-SWITCH data lend that premise direct head-to-head support for the first time: gastrointestinal safety remained favorable in the ecnoglutide arm, consistent with the earlier Phase 3 SLIMMER trial, where the discontinuation rate due to GI adverse events was 0.6% across 664 patients over 48 weeks
Discussion GLP-1RAs have changed the therapeutic paradigm of T2D as they significantly improve glucose control, also contributing to pleiotropic effects, especially at the cardiovascular level (60), in different clinical scenarios and therapeutic approaches
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