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Optimal administration technique is crucial for efficacy: Take Rybelsus on an empty stomach first thing in the morning Swallow the tablet whole with no more than 120 ml (half a glass) of plain water Wait at least 30 minutes before eating, drinking, or taking other oral medications Do not split, crush, or chew the tablet, as this reduces absorption Take at the same time each day for consistent effect These specific instructions exist because semaglutide has poor oral bioavailability, and food or excessive fluid significantly impairs absorption
Nishikori K et al
Its levels in the body may decrease by a number of factors including poor nutrition, stress and age
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