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These trials, including STEP-1 through STEP-6, highlighted semaglutides superiority over placebo and other treatments, such as liraglutide, in promoting weight loss and enhancing cardiometabolic parameters, including blood pressure and lipid profiles [6][15]

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Mutations identified in patients with defective lipoic acid metabolism affect genes involved in the synthesis of iron-sulfur clusters and genes coding for lipoic acid synthetase ( LIAS ), lipoyl transferase 1 ( LIPT1 ), and dihydrolipoamide dehydrogenase (E3 component of -ketoacid dehydrogenase complexes

1 Prior research has shown conflicting results on GLP-1 medications and thyroid function