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B., Mitchell, J

[9] Mechanistically, cagrilintide is thought to reduce body weight primarily by acting on both homeostatic appetite centers (the physiological hunger/fullness system) and hedonic ones (the reward-driven side of eating), lowering food intake without directly forcing energy expenditure up

This means a lower and less predictable amount of the active compound might reach systemic circulation, potentially requiring higher doses and introducing variability into research findings

This matters because Ozempic users don't need additional appetite stimulation, and hormonal disruptions could complicate their protocol