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In preclinical and in-vitro studies, tirzepatide has been investigated for its concurrent engagement of two incretin receptor pathways, with reported effects on cyclic AMP signaling, beta-cell physiology, and glucose-dependent insulin secretion in cell-based and animal models
However, only about 1 in 4 patients were over 70, and relatively few cases of dementia were identified among the participants
Data use agreements and institutional IRB will be required
Most safety information comes from preclinical animal studies and practitioner experience reports
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