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Chest pain is not listed as a common or direct side effect of semaglutide in clinical trials or product labeling

The 2024 structural study in Cell Research examined receptor recognition across GLP-1R, GIPR, and GCGR and reported that triple agonism involves conserved interactions along with receptor-specific contacts in the transmembrane domain pocket

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The comparative effectiveness of an expanded 2-year on-treatment analysis that followed patients who stay on the exposure or comparator therapies for a prolonged time showed concordant results with the 1-year on-treatment analysis (Supplementary Table 25)