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10.1186/s12882-021-02278-1 3

Dikici I, Mehmetoglu I, Dikici N, Bitirgen M, Kurban S

Humans cannot produce nitric oxide from nitrate without these bacteria ( Research has shown that mouthwash kills the oral bacteria needed to produce nitric oxide for up to 12 hours ( This leads to a decrease in nitric oxide production and, in some instances, an increase in blood pressure ( The detrimental effects of mouthwash on nitric oxide production may even contribute to the development of diabetes, which is characterized by malfunctions in insulin production or action

The American journal of clinical nutrition , 94 (3), 847853