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Published online November 28, 2023

[20] [21] Your healthcare provider will also investigate potential causes of iron deficiency, which may include: Dietary inadequacy (particularly relevant with significant appetite suppression) Gastrointestinal blood loss (requiring investigation if no obvious cause) Menstrual blood loss in premenopausal women Malabsorption disorders such as coeliac disease Chronic inflammation or other underlying conditions NICE guidance (NG12) recommends urgent suspected cancer referral (two-week wait) for adults aged 60 and over with iron deficiency anaemia

Furthermore, when serum from SLE patients was incubated with RBCs from healthy donors, significant PS exposure and increased intracellular calcium influx were observed, although the cell size remained unchanged [328]