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Common Side Effects: Nausea and Vomiting : Frequently occurs when starting semaglutide or increasing the dose Diarrhea: Common during the initial phase of treatment Constipation : Affects some patients during treatment Abdominal Pain : This may occur, often mild to moderate Headache : This can occur, especially at the start of treatment Fatigue : Ensure sufficient rest and a balanced diet

Valine, leucine, and isoleucine biosynthesis, ECM-receptor interaction, African trypanosomiasis, fluid shear stress and atherosclerosis, bacterial invasion of epithelial cells, human cytomegalovirus infection, hematopoietic cell lineage, focal adhesion, Fc gamma R-mediated phagocytosis, and cell adhesion molecules, resulted as significant enrichment pathways ( Figure 6A , Table 3 )