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National Center for Complementary and Integrative Health notes that randomized, placebo-controlled trials are the gold standard because they help determine whether apparent improvement is due to the treatment or to chance

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At the same time, rosmarinic acid promotes the upregulation of TH and brain-derived neurotrophic factor (BDNF) genes to alleviate the cytotoxicity of H 2 O 2 -induced N2A cells (Ghaffari et al., 2014)