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NUPR1 inactivation can regulate mitochondria-related ferroptosis through mitochondrial dysfunction, decreased antioxidant capacity, and increased accumulation of endogenous iron content [84]

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Not only did primary analysis reveal reduced death from cardiovascular causes and non-fatal myocardial infarction overall, but prespecified secondary analysis also showed that, among patients with atherosclerotic disease and heart failure, there were reduced composite heart failure hospitalizations and cardiovascular deaths among patients taking semaglutide

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